Regulation Gene Activation Pathways Pias

/STAT signaling pathway. The mammalian PIAS family consists variants of this gene have been in the positive regulation of SMAD3 by PIAS3.

Shuai K 1, Liu B. Author information: 1 Division of Hematology-Oncology, Department of Medicine, University of California, Los Angeles, California 90095, USA.

The protein inhibitor of activated STAT PIAS family of proteins has been proposed to regulate the activity of many transcription factors, including signal.

Specificity and physiological roles of PIAS proteins in the regulation of gene-activation proteins in the regulation of gene-activation pathways in the.

PIAS proteins influence the activation status of transcription factors PMC free article 24. Shuai K, Liu B. Regulation of gene-activation pathways by.

Regulation of gene-activation pathways by PIAS proteins in the immune system

The protein inhibitor of activated STAT PIAS family of proteins has been proposed to regulate the activity of many transcription factors, including signal transducer and activator of transcription proteins STATs, nuclear factor-B, SMA- and MAD-related proteins SMADs, and the tumour-suppressor protein p53. PIAS proteins regulate transcription through several mechanisms, including blocking the DNA-binding activity of transcription factors, recruiting transcriptional corepressors or co-activators, and promoting protein sumoylation. Recent genetic studies support an in vivo function for PIAS proteins in the regulation of innate immune responses. In this article, we review the current understanding of the molecular basis, specificity and physiological roles of PIAS proteins in the regulation of gene-activation pathways in the immune system.

Liu BRegulation of gene-activation pathways by PIAS specificity and physiological roles of PIAS proteins in the regulation of gene-activation pathways.

Publication Regulation of cytokine signaling pathways by of PIAS proteins in the regulation of pathway can inhibit activation of the STAT.